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. Author manuscript; available in PMC: 2016 May 3.
Published in final edited form as: JCI Insight. 2016 Mar 17;1(3):e84738. doi: 10.1172/jci.insight.84738

Figure 3. Reactivity of VLRB MM3 with distinct subpopulations of human PCs and plasmablasts.

Figure 3

Top row: Human BM PCs were gated on IgD−/CD38++ cells and further subdivided into population “A” (CD19+/CD138−); population “B” (CD19+/ CD138+); population “C” (CD19−/CD138−); and population “D” (CD19−/CD138+). The various subpopulations were analyzed for reactivity with VLRB MM3 (black histogram) or negative control VLR4 (gray histogram). Shown is a representative of 3 BM samples. Bottom row: Plasmablasts from PBMCs collected on day 7 following vaccination were divided on the basis of CD138 expression and analyzed for reactivity with VLRB MM3 (black histogram) or negative control VLR4 (gray histogram). Shown is a representative of 8 vaccinated PBMC samples. PBMCs, peripheral blood mononuclear cells; PCs, plasma cells; Pop., population; VLR, variable lymphocyte receptor.