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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Am J Surg Pathol. 2016 Sep;40(9):1232–1242. doi: 10.1097/PAS.0000000000000659

Figure 5. Electron microscopy examination of sphingomyelin accumulation and clearance from Hepatocytes.

Figure 5

Panel A demonstrates the presence of large sphingomyelin masses (SM) mixed with lipofuscin (L) within hepatocytes at baseline in patient 5. Smaller whorls of sphingomyelin are also present (black arrows). Panel B demonstrates the reduction of sphingomyelin after 26 weeks of olipudase alfa treatment. Black arrows indicate residual sphingomyelin. EM scale bars = 1μm.