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. Author manuscript; available in PMC: 2016 May 16.
Published in final edited form as: Cold Spring Harb Perspect Biol. 2014 Jul 1;6(7):a015826. doi: 10.1101/cshperspect.a015826

Figure 5. Regulation.

Figure 5

(A) Diagram showing the tension-dependent deformation of the kinetochore structure. Aurora B kinase located at the inner centromere (at the base of the kinetochore) is spatially separated from its substrates at the outer kinetochore. The presence of tension on bi-oriented kinetochores strongly reduces the ability of Aurora B to phosphorylate outer kinetochore proteins and inactivate microtubule attachments. (B) Model showing the spindle assembly checkpoint proteins preventing cell cycle progression in the absence of unattached kinetochores.