Alteration in gene expression in SAEC due to CoO and La2O3 nanoparticles. cDNA generated from RNA was isolated from SAEC treated with 0.0, 5.0, 25.0, and 50.0 μg/ml administered dose for 6 h with CoO and La2O3 nanoparticles. cDNA was then assayed with TaqMan qRTPCR for the following genes: (A) NOS2, (B) MT3, (C) PTGS2(COX2), and (D) SOD3. Samples were normalized to internal control 18 s. The values represent a fold induction compared to 0.0 μg/ml control (1.0). n = 3, * indicates P < .05 compared to La2O3 nanoparticles at the same administered dose.