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. Author manuscript; available in PMC: 2017 Sep 25.
Published in final edited form as: Mol Psychiatry. 2016 Jul 26;22(10):1440–1447. doi: 10.1038/mp.2016.118

Figure 2. Antidepressants restore p11 levels in PrL and alleviate stress-induced depression.

Figure 2

(a,b) Western blot measurement of p11 protein (a) and qPCR measurement of p11 mRNA (b) in PrL from control and stressed mice with or without antidepressant treatments (a, n = 10 CON, n = 12 for each group of RST, RST+Imi, RST+Flu, RST+Esci; b, n = 6 per group). (c–f) Depression-like behaviors in control and stressed mice with or without antidepressant treatments, as measured by TST (c), FST (d), SPT (e) and NSF (f) (n = 10 CON, n = 12 for each group of RST, RST+Imi, RST+Flu, RST+Esci). # P < 0.05, ## P < 0.01, compared to CON; * P < 0.05 and ** P < 0.01, compared to RST, one-way ANOVA. Imi, imipramine; Flu, fluoxetine; Esci, escitalopram. Data are means ± s.e.m.