Subgroup analysis identified 2 distinct viral profiles present in the pSS patient population tested. (A) Cluster analysis of the 13 probes identified through subgroup analysis rendered 2 virus profiles. Virus profile I contained probes for deltavirus, Astroviridae, Circoviridae, and Herpesviridae. Virus profile II contained probes for Flaviviridae, Picornaviridae, Parvoviridae, and Herpesviridae. (B) Pairwise correlation of probes identified through subgroup analysis further defined the 2 divergent virus profiles.