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. Author manuscript; available in PMC: 2016 Jun 10.
Published in final edited form as: Pathog Immun. 2016 May;1(1):12–40. doi: 10.20411/pai.v1i1.72

Figure 3.

Figure 3

Viral microarray analysis identified HDV in 50% of the patients tested and was confirmed through detection of HDV sequence and antigen in salivary gland tissue. (A) Viral microarray analysis rendered a significant increase in HDV in pSS patients relative to healthy controls (P<.05, n=26). (B) qPCR confirmed the presence of HDV sequence detected in 50% of pSS samples tested. Sicca patients were also positive for the presence of HDV sequence. Secondary confirmation was performed by an independent lab and detected HDV in 50% of samples tested (Supplemental Figure 1). (C) HDV antigens were detected in paraffin-embedded salivary gland tissue and rendered a nuclear staining pattern consistent with prior studies of HDV protein localization.