Table 1.
Clinical parameters of primary Sjögren’s syndrome, primary Sjögren’s syndrome-HDVhigh or primary Sjögren’s syndrome-HDVlow relative to healthy control cohort.
| Healthy Controls | Primary Sjögren’s Syndrome | Primary Sjögren’s Syndrome | ||
|---|---|---|---|---|
| HDVlow | HDVhigh | |||
|
|
|
|||
| Age | 42±9 | 50±13 | 54±12# | 48±14 |
| Sex (F/M) | 8/7 | 8/7 | 3/4 | 5/3 |
| Total Unstimulated Saliva Flow | 4.77±5.15 | 1.22±1.48* | 1.04±1.40 | 1.38±1.63 |
| Total Stimulated Saliva Flow | 18.28±11.27 | 9.14±6.49* | 7.56±7.19# | 10.53±5.94 |
| Focus Score | 0.36±0.63 | 1.87±1.25** | 2.43±1.27### | 1.37±1.06# |
| Schirmer’s Test | 19.2±12.07 | 5.5±4.9** | 3.8±2.8## | 7±6.0# |
| Anti-Nuclear Antibodies (% Positive) | 0% | 87%*** | 100%### | 75%## |
| Anti-SSA/Ro Antibodies (% Positive) | 0% | 80%*** | 86%### | 75%### |
| Anti-SSB/La Antibodies (% Positive) | 0% | 67%*** | 86%### | 50%# |
| Rheumatoid Factor (% Positive) | 17% | 60%* | 86%# | 38% |
| IgG (Serum) | 1146±269 | 1673±578* | 1859±663## | 1488±453 |
| IgM (Serum) | 137±85 | 104±37 | 95±37 | 113±38 |
| C3 COMPLEMENT | 124±22 | 112±29 | 105±23 | 118±35 |
| C4 COMPLEMENT | 26±10 | 21±9 | 21±8 | 21±10 |
| WBC Count | 5.76±1.44 | 5.09±1.44 | 5.39±1.79 | 4.79±1.02 |
| Lymphocyte Count | 30.7±6.2 | 36.0±8.7 | 34.4±8.8 | 37.6±9.0 |
| Monocyte Count | 7±3 | 9±1* | 9±2 | 9±1 |
| Hematocrit | 42.1±2.9 | 41.6±1.4 | 41.7±2.4 | 41.4±4.6 |
| Sed Rate | 17±9 | 14±8 | 18±9 | 10±5 |
| Hemoglobin | 14.1±1.0 | 14.0±1.1 | 14.1±0.7 | 13.8±1.5 |
| Platelets | 281±45 | 251±76 | 248±89 | 255±66 |
| Albumin | 4.2±0.3 | 4.1±0.3 | 4.0±0.2 | 4.3±0.2☨ |
| Alkaline Phosphatase (ALP) | 71±20 | 64±15 | 66±15 | 62±16 |
| Alanine Transaminase (ALT) | 24±11 | 27±11 | 24±7 | 30±14 |
| Amylase | 72±33 | 92±28 | 100±33 | 83±21 |
| Aspartate Aminotransferase (AST) | 24±6 | 31±23 | 26±6 | 37±32 |
| Calcium | 2.32±0.09 | 2.39±0.13 | 2.32±0.10 | 2.45±0.13 |
| Chloride | 104±3 | 104±1 | 103±1 | 104±1 |
| Creatinine | 0.80±0.18 | 0.84±0.16 | 0.83±0.18 | 0.84±0.15 |
| Glucose | 98±15 | 92±6 | 92±7 | 91±6 |
| Magnesium | 0.90±0.7 | 0.88±0.06 | 0.85±0.5 | 0.90±0.07 |
All values are mean±standard deviation unless otherwise stated. Statistically significant values in primary Sjögren’s Syndrome versus healthy controls *P<.05, **P<.005, ***P<.0005, n=10–15. Statistically significant values in Primary Sjögren’s Syndrome HDVlow versus Primary Sjögren’s Syndrome HDVhigh ☨P<.05, n=6–8. Statistically significant values in Primary Sjögren’s Syndrome HDVhigh or Primary Sjögren’s Syndrome HDVlow versus healthy controls #P<.05, ##P<.005 ###P<.0005, n=6–15. HDVhigh is defined as samples possessing normalized microarray intensity values above 95% Confidence Interval based on healthy controls. HDVlow is defined as samples possessing normalized microarray intensity values within the 95% Confidence Interval based on healthy controls. Statistical analysis was evaluated by t-test or fisher’s exact test for categorical data.