Table 1.
Demographic and clinical information of the studied subjectsA
Demographics | Clinical measures | Serology | Other | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Subject | Age (yr) | RaceB | FSC | WUSFD | vBjstE | SchirF | RoG | LaH | RFI | EGMJ | EGCK |
1 | 48 | EA/AI | 1.3/+ | 4.786/− | 4/+ | 13/− | − | − | − | − | Ind |
2 | 51 | EA | 9/+ | 3.799/− | 6/+ | 2/+ | + | + | + | + | − |
3 | 35 | EA | 4/+ | 11.774/− | 8/+ | 22/− | − | − | − | + | + |
4 | 35 | EA | 5.7/+ | 3.158/− | 4/+ | 14/− | + | − | + | + | − |
5 | 58 | EA | 12/+ | 0.030/+ | 9/+ | 2/+ | + | + | + | + | + |
6 | 43 | EA/AI | 1.8/+ | 2.819/− | 4/+ | 25/− | − | − | − | − | Ind |
7 | 49 | EA | 2/+ | 1.879/− | 6/+ | 9/− | + | − | − | − | − |
8 | 60 | EA | 3/+ | 3.182/− | 4/+ | 25/− | + | − | + | + | + |
9 | 69 | EA/AI | 4.6/+ | 0.631/+ | 3/− | 8/− | − | + | − | − | + |
10 | 30 | EA/AI | 4/+ | 0.001/+ | 9/+ | 1/+ | + | + | + | + | Ind |
All participants were women reporting symptoms of dry eyes and dry mouth and fulfilling both the American-European Consensus Group and American College of Rheumatology criteria for pSS. “+” indicates a positive test for the indicated parameter. “−” indicates a negative test for the indicated parameter. Disease duration (diagnosis or classification) was less than or equal to 1 year for all participants except subject 5, who had a disease duration of 11 years.
EA, self-reported European American descent; EA/AI, self-reported mixed European American/American Indian descent.
FS, focus score.
WUSF, whole unstimulated salivary flow (ml/15 min).
vBjst, van Bijsterveld ocular surface staining score, highest value (most abnormal) eye.
Schirmer’s tear flow (mm/5 min), lowest value (most abnormal) eye.
Ro (+): positive antibody test at clinic visit or in medical record.
La (+): positive antibody test at clinic visit or in medical record.
RF, rheumatoid factor.
EGM, extraglandular manifestation of one or more of the following: hypergammaglobulinemia, Raynaud’s phenomenon, peripheral neuropathy, elevated erythrocyte sedimentation rate, arthritis (synovitis), leukopenia, or hypocomplementemia.
EGC, ectopic germinal center-like structure in SG. Ind, indeterminate.