Table 4.
TCR sequences of clonally expanded CD4+ T cells in pSS PB
| Exp clone ID | No. repeats/total | Vα gene | Vα | N | Jα | Jα gene | Vβ gene | Vβ | NDN | Jβ | Jβ gene |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PB1A | 2 | TRAV13-1 | CAAT | E | STGFQKLVF | J8 | TRBV20-1 | CSAR | GL | AGVEQFF | J2-1 |
| PB3A | 2 | TRAV8-4 | CAASG | E | TGFQKLVF | J8 | ND | ||||
| PB3B | 2 | TRAV5-1 | CAESI | DDYKLSF | J20 | ND | |||||
| PB4A | 2 | TRAV8-6 | CAVS | GINAGKSTF | J27 | TRBV7-6 | CASSLE | QPERL | TYNEQFF | J2-1 | |
| PB7A | 3 | TRAV13-1 | CAA | QG | GNFNKFYF | J21 | TRBV29-1 | CSVG | EG | DTEAFF | J1-1 |
| PB9A | 2 | TRAV13-1 | CAA | GG | PGYSSASKIIF | J3 | TRBV20-1 | CSARD | YTSGSA | TYNEQFF | J2-1 |
| PB9B | 3 | TRAV8-1 | CAV | GLE | SARLMF | J31 | TRBV20-1 | CSA | WSLAGDR | AYNEQFF | J2-1 |
| PB9C | 2 | TRAV26-1 | CIVR | PP | DGQKLLF | J16 | TRBV19 | CASSI | QGA | TGELFF | J2-2 |
The ID listed for each expanded (Exp) clone indicates subject number and that it was derived from peripheral blood (PB). The complete T cell receptor (TCR) gene usage, complementarity-determining region (CDR3) sequences, and the number of sequence repeats detected are listed. None of the PB clones had a second TCRα chain detected. ND, not determined.