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Antigen-induced UCP2 expression regulates CD8+ T cell clonal expansion, metabolic reprogramming and differentiation. Antigen stimulation of naïve CD8+ T cells with three requisite signals induces UCP2 expression by 24 h to achieve balanced metabolic reprogramming (lower ECAR/OCR), clonal expansion (lower apoptosis) of effector CD8+ T cells (CD62Llo KLRG1Hi IFNγInt).
