Table 5.

Adverse events

System	Adverse event :No. of patients (%)
Hematologic	Neutropenia*   Grade 4: 1 (7%)   Grade 3: 3 (23%)   Grade 2: 1 (7%)
Infectious	Upper respiratory (URI):5 (38%) Sinusitis: 2 (15%) Influenza: 1 (7%)
Rheumatologic	Gout: 2 (15%) Elevated CPK: grade 1: 3 (23%)
Neurologic	Dysesthesias (hands and/or feet): Grade 1: 3 (23%) Tremor: Grade 1: 1 (7%) Headache: 3 (23%)
GI:	Hyperbilirubinemia: Grade 1: 3 (23%) Other Liver test abnormalities (ALT): Grade 1: 2 (15%) Dyspepsia: 2 (15%)
CV	New onset hypertension requiring therapy: 2 (15%) Worsening of hypertension requiring additional therapy: 5 (39%)
Metabolic	Hyperkalemia: Grade 2: 1 (7%); Grade 1: 2 (15%) Hypomagnesemia: Grade 1: 3 (23%) Hyperglycemia: 1 (7%)
Other	Increased hair growth or coarser hair: 4 (30%) Gingival hyperplasia: 1 (7%)

Grading based on NCI Common Toxicity Criteria for Adverse Events (NCI CTCAE) version 4.0