Table 4.

Multivariable-adjusted^* hazard ratios (HR) and 95% confidence intervals (95%CI) for cardiovascular events according to migraine status, stratified by ACE D/I genotype in the Women's Health Study (N=25,000)

Ischemic vascular events	No history of migraine, (n=20,423) Referent	Any history of migraine (n=4,577)	P value	Active migraine with aura (n=1,275)	P value	Active migraine without aura (n=1,951)	P value	Prior migraine (n=1,351)	P value
Major cardiovascular event†	N=504	N=121		N=48		N=32		N=41
Overall	1.00	1.30 (1.06-1.58)	0.01	2.07 (1.53-2.79)	<0.0001	0.98 (0.68-1.40)	0.90	1.10 (0.80-1.51)	0.56
DD genotype	1.00	1.40 (0.98-2.00)	0.07	2.10 (1.22-3.59)	0.007	1.34 (0.77-2.33)	0.31	0.98 (0.52-1.87)	0.96
DI genotype	1.00	1.41 (1.06-1.88)	0.02	2.31 (1.52-3.51)	<0.0001	0.93 (0.54-1.60)	0.78	1.28 (0.82-1.99)	0.27
II genotype	1.00	0.90 (0.56-1.43)	0.65	1.47 (0.71-3.03)	0.30	0.49 (0.18-1.35)	0.17	0.91 (0.46-1.80)	0.79
Ischemic Stroke	N=228	N=47		N=20		N=14		N=13
Overall	1.00	1.12 (0.81-1.53)	0.50	1.90 (1.19-3.01)	0.007	0.97 (0.56-1.67)	0.90	0.77 (0.44-1.34)	0.35
DD genotype	1.00	1.22 (0.69-2.16)	0.49	1.97 (0.84-4.59)	0.12	1.04 (0.41-2.62)	0.93	0.90 (0.33-2.49)	0.84
DI genotype	1.00	0.92 (0.56-1.51)	0.74	2.07 (1.10-3.87)	0.02	0.73 (0.30-1.80)	0.49	0.36 (0.11-1.13)	0.08
II genotype	1.00	1.26 (0.68-2.33)	0.46	1.33 (0.41-4.31)	0.64	1.14 (0.41-3.21)	0.80	1.31 (0.56-3.07)	0.53
Myocardial Infarction	N=217	N=51		N=22		N=13		N=16
Overall	1.00	1.23 (0.90-1.67)	0.19	2.12 (1.36-3.31)	0.001	0.87 (0.50-1.53)	0.64	0.99 (0.60-1.65)	0.98
DD genotype	1.00	1.46 (0.89-2.40)	0.13	2.57 (1.31-5.04)	0.006	1.31 (0.59-2.87)	0.51	0.79 (0.29-2.17)	0.65
DI genotype	1.00	1.58 (1.02-2.47)	0.04	2.49 (1.29-4.83)	0.007	1.00 (0.43-2.30)	0.99	1.56 (0.81-3.01)	0.19
II genotype	1.00	0.35 (0.13-0.97)	0.04	0.72 (0.17-2.98)	0.65	----	0.98	0.43 (0.11-1.78)	0.25

^*Controlling for: age, body mass index, diabetes, physical activity, postmenopausal hormone use, oral contraceptive use, history of hypertension, alcohol consumption, smoking categories, and family history of myocardial infarction.

^†Defined as the first of any of these events: nonfatal ischemic stroke, nonfatal myocardial infarction, or death due to ischemic cardiovascular cause.