. Author manuscript; available in PMC: 2016 Jul 11.

Published in final edited form as: J Renin Angiotensin Aldosterone Syst. 2016 Jun 9;17(2):10.1177/1470320316652032 1470320316652032. doi: 10.1177/1470320316652032

Table 1.

Clinical variables before and during add-on hydrochlorothiazide (HCTZ) treatment.

	ARB	ARB+HCTZ	p Value
Body weight (kg)	61.9±15.2	61.5±15.0	0.2
GFR (ml/min)	66±47	59±38	0.04
S_Na (mEq/l)	141±2	139±3	0.002
S_K (mEq/l)	4.4±0.6	4.3±0.5	0.1
S_Cr (mg/dl)	1.7±1.3	1.8±1.4	0.02
S_UA (mg/dl)	6.5±1.3	7.1±1.3	0.006
HbA1c (%)	5.9±0.6	6.1±0.8	0.05
PRA (ng/ml/h)	2.5±3.2	4.3±3.3	0.01
PAC (pg/ml)	121±61	155±99	0.09
Ang I (pg/ml)	215±3	382±4	0.009
Ang II (pg/ml)	16±2	21±3	0.08

Ang I: angiotensin I; Ang II: angiotensin II; ARB: angiotensin receptor blocker; GFR: glomerular filtration rate; HbA1c, haemoglobin A1C; PAC: plasma aldosterone concentration; PRA: plasma renin activity; S_Na, S_K, S_Cre, S_UA: serum concentrations of sodium, potassium, creatinine, uric acid, respectively; SD: standard deviation.

Values are means±SD (n=23).