. Author manuscript; available in PMC: 2016 Jul 11.

Published in final edited form as: J Renin Angiotensin Aldosterone Syst. 2016 Jun 9;17(2):10.1177/1470320316652032 1470320316652032. doi: 10.1177/1470320316652032

Table 2.

Blood pressures, heart rates, and urinary excretion of albumin, sodium, and angiotensinogen before and during add-on hydrochlorothiazide (HCTZ) treatment.

Variable		ARB	ARB+HCTZ	p Value
SBP	Office (mmHg)	147±9	124±13	<0.0001
	24-Hour (mmHg)	132±14	118±15	<0.0001
	Day (mmHg)	134±13	120±15	0.0003
	Night (mmHg)	127±17	113±19	0.0003
	Night/day ratio	0.95±0.06	0.94±0.10	0.7
DBP	Office (mmHg)	83±12	76±14	0.04
	24-Hour (mmHg)	79±11	72±10	0.0003
	Day (mmHg)	81±11	75±10	0.0008
	Night (mmHg)	73±12	67±11	0.002
	Night/day ratio	0.91±0.06	0.90±0.08	0.7
MAP	Office (mmHg)	104±9	92±13	0.0002
	24-Hour (mmHg)	96±10	87±11	0.0001
	Day (mmHg)	98±10	89±11	0.0003
	Night (mmHg)	91±12	82±13	0.0009
	Night/day ratio	0.93±0.06	0.92±0.08	0.6
HR	Office (rpm)	71±15	74±12	0.2
	24-Hour (rpm)	68±8	68±8	0.9
	Day (rpm)	71±9	72±9	0.4
	Night (rpm)	61±6	61±8	0.8
	Night/day ratio	0.88±0.10	0.85±0.08	0.3
U_AlbV	24-Hour (mg/g Cre)	419±6	237±7	0.0007
	Day (mg/h)	16.07±6.14	9.40±6.43	0.003
	Night (mg/h)	16.52±4.99	8.79±6.44	0.001
	Night/day ratio	1.55±1.82	1.12±0.79	0.7
U_NaV	24-Hour (mmol/g Cre)	152±63	164±63	0.3
	Day (mmol/h)	6.45±3.77	6.60±2.79	0.9
	Night (mmol/h)	6.66±4.09	6.55±3.55	0.9
	Night/day ratio	1.23±0.90	1.11±0.62	0.9
U_AGTV	24-Hour (μg/g Cre)	152±10	82±17	0.02
	Day (μg/h)	7.06±0.01	2.81±0.02	0.001
	Night (μg/h)	3.21±0.01	2.73±0.01	0.4
	Night/day ratio	0.80±0.88	2.97±6.96	0.05

ARB: angiotensin receptor blocker; /gCre: per gram creatinine; DBP: diastolic blood pressure; HR: heart rate; MAP: mean arterial pressure; SBP: systolic blood pressure; SD: standard deviation; U_AlbV, U_NaV, and U_AGTV: urinary excretions of albumin, sodium, and angiotensinogen, respectively.

Values are means±SD (n=23).