Skip to main content
. Author manuscript; available in PMC: 2017 Dec 2.
Published in final edited form as: Virus Res. 2016 Jul 7;226:142–151. doi: 10.1016/j.virusres.2016.07.003

Figure 4. Mutations accumulated in PEDV S protein with passages in cell cultures.

Figure 4

The grey bars indicate the overall structure of PEDV S protein, indicating S1 and S2 domains. Different functional motifs are also represented, such as the signal peptide (SP), heptad-repeats domains (HR1 and HR2), and transmembrane domain (TM). In addition, the described domains inducing neutralizing antibodies are also represented (NE1, NE2 and NE3). Comparison was performed between virulent (GenBank JQ023161) and attenuated DR13 (JQ023162) strains, and 83P-5 parental strain (P0, AB548618) and virus passaged 34 (P34, AB548619), 61 (P61, AB548620) and 100 times (P100, AB548621) in Vero cells. Vertical bars into the dark blue rectangles represent non-silent point mutations that were identical (yellow bars) or different (red bars) between DR13 and 83P-5 P100 vaccine strains. The common deletion in the N-terminal is represented by the vertical white bar.