. Author manuscript; available in PMC: 2017 Apr 27.

Published in final edited form as: NPJ Genom Med. 2016 Apr 27;1:16006. doi: 10.1038/npjgenmed.2016.6

Table 1. Non-additive genetic interaction of prioritized inter-inter and inter-intra Lead SNP pairs validated in independent GWAS studies.

Entropy-based p-values correspond to the observed statistical pattern of epistasis. SNP rs4509693 was associated with both cis and trans-eQTLs, but all other eQTL relationships were trans. Asterisks are used to indicate intragenic SNPs with host gene listed below.

Disease	Prioritized SNP pairs	SNPs with synergistic effects	Entropy p-value
Alzheimer’s	rs4509693 (chr10, inter) - rs753129b (chr4, inter)	rs4509693 - rs753129 - rs7081208*	0.046
Alzheimer’s	rs7081208* (chr10, FRMD4A) - rs9331888* (chr8, CLU, MIR6843)

Bladder cancer	rs8102137 (chr19, inter) - rs1014971 (chr22, inter)	rs8102137 - rs1014971	0.039