Table 3.
─ Shared mutations identified in pairs of LCIS - LCIS lesions.
| Case number |
Lesion | Side-Quadrant | CDH1 | PIK3CA | CBFB | PKHD1L1 |
|---|---|---|---|---|---|---|
| 10 | LCIS-1 | R-UOQ | Q23* (21%) |
H1047L (22%) |
V4L (27%) |
- |
| LCIS-2 | R-UIQ | Q23* (18%) |
H1047L (22%) |
V4L (19%) |
- | |
| 13 | LCIS-1 | L-UOQ | E336_splice (25%) |
- | - | V1686I (17%) |
| LCIS-2 | L-LOQ | E336_splice (7%) |
- | - | V1686I (10%) |
|
| 53 | LCIS-1¥φ | R-UIQ | I178_splice (25%) |
- | - | - |
| LCIS-2¥φ | R-UIQ | I178_splice (7%) |
- | - | - |
ILC, invasive lobular cancer; L, left side; LCIS, lobular carcinoma in situ; LIQ, lower inner quadrant; LOQ, lower outer quadrant; MAF, mutant allele fraction; R, right side; UIQ, upper inner quadrant; UOQ, upper outer quadrant;
¥
same quadrant;
φ
samples also subjected to whole-exome sequencing. For each gene/ mutation, the amino acid change and the mutant allele fraction are shown. Shared mutations were identified in 3/10 pairs of LCIS-LCIS.