Fig. 3.

Proposed sequence of events following aberrant fatty acid reabsorption at the apical surface of the proximal tubule in the setting of nephrotic syndrome. The numbers signify the order of metabolic pathway activation. ACSL1 long chain acyl-CoA synthetase-1, Alb albumin, CPTla carnitine palmitoyl transferase-la, DAG diacylglycerol, FA TP fatty acid transport protein, LC-CoA long chain fatty acyl-CoA, NEFA non-esterified fatty acid, NHE1 Na⁺–H⁺ exchanger-1, PI(4,5)P2 phosphatidylinositol 4,5-bisphosphate