. Author manuscript; available in PMC: 2017 Jul 10.

Published in final edited form as: J Clin Oncol. 2016 Mar 21;34(20):2359–2365. doi: 10.1200/JCO.2015.63.1960

Table 4.

Multivariate Cox Models for Time to First Progression and 2-Year Overall Survival Among ER Positive/HER2 Negative Patients Presenting with de novo Stage IV Disease.

	Time to First Progression
	Hazard Ratio	95% CI	p-value
Recurrence score, 50pt	5.36	1.28–22.51	0.022
Recurrence score, 10pt	1.40	1.05–1.86	0.022
Age at diagnosis, years	0.99	0.96–1.02	0.660
Tumor size, cm	1.07	0.94–1.22	0.311
Site first metastases	0.57	0.28–1.16	0.123
	2-Year Overall Survival
	Hazard Ratio	95% CI	P value
Recurrence score, 50pt	20.58	1.89–224.2	0.013
Recurrence score, 10pt	1.83	1.14–2.95	0.013
Age at diagnosis, years	1.01	0.97–1.06	0.655
Tumor size (cm)	1.00	0.79–1.25	0.972
Site first metastases	0.83	0.28–2.48	0.737

Adjusted Cox Models, RS and age as continuous variables, site 1^st metastases: bone only versus other.

Abbreviations: ER, estrogen receptor; CI, confidence interval.