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. Author manuscript; available in PMC: 2016 Nov 23.
Published in final edited form as: Pain. 2016 Dec;157(12):2709–2721. doi: 10.1097/j.pain.0000000000000690

Figure 4. Ang-(1-7) administration in established CIBP does not change nesting behaviors.

Figure 4

Nesting, an innate behavior of mice, was studied. During the first hour of the study, the 66.1-inoculated animals, day 6 post-surgery, cleared significantly (p < 0.05) fewer zones than naïve animals (A). After the second hour of the study, the media animals cleared fewer zones than both the naïve and 66.1-inoculated animals (p < 0.05). A second study was conducted in which 66.1-inoculated animals, day 15 post-surgery, were treated with Ang-(1-7) (0.058 μg/kg, i.p.) or vehicle (0.9% saline) (B). The nesting behaviors of both cancerous groups did not differ significantly from the naïve group. At both 75 and 90-minute time points, media animals cleared fewer zones than the other three groups (p < 0.05). Values represent the mean ± standard error of the mean, n=8 per group.