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. Author manuscript; available in PMC: 2016 Nov 23.
Published in final edited form as: Pain. 2016 Dec;157(12):2709–2721. doi: 10.1097/j.pain.0000000000000690

Figure 7. Repeated dosing of Ang-(1-7) does not affect bone remodeling of mice with established CIBP.

Figure 7

(A) Representative day 14 radiographs of chronically treated animals. (B) Day 14 images were scored by three blinded observers with the following scale: 0 – healthy bone, 1 – 1–3 lesions, 2 – 4–6 lesions, 3 – unicortical fracture, 4 – bicortical fractures. Both saline and Ang-(1-7)-treated cancerous animals experienced unicortical fractures. (C) Levels of carboxy-terminal collagen crosslinks (CTX) in the serum were quantified as another measure of bone remodeling. While cancer-inoculation significantly increased (p < 0.05) CTX levels in the bone compared to both media controls. Ang-(1-7) repeated administration did not significantly alter CTX levels compared to the 66.1, saline treated group.