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. Author manuscript; available in PMC: 2017 Mar 10.
Published in final edited form as: Gene Expr. 2016 Aug 18;17(2):115–127. doi: 10.3727/105221616X692991

Figure 5. Partial bile duct ligation induces localized ATZ globule clearance in PiZZ mouse liver.

Figure 5

A. Serum ALT, alkaline phosphatase, and total bilirubin levels in mice 14 days after pBDL are comparable to age- and sex-matched unoperated PiZZ (control) mice. As expected, biochemical parameters in BDL mice (shown in Figure 1A) are significantly worse compared to pBDL values. B. Quantitative results of ATZ globule morphometry showing decreased percentage of PASD globules present in the ligated left lobe (pBDL) compared to the unligated right control lobe. C. PASD staining showing the cleared areas of ATZ globules in pBDL (ligated left lobe, right panel) compared to control (unligated right lobe, left panel). Arrows point to residual GC hepatocytes intermixed within areas of ductal proliferation, similar to total BDL (200× magnification).