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. Author manuscript; available in PMC: 2017 Apr 6.
Published in final edited form as: J Magn Reson Imaging. 2016 Sep 30;45(4):1144–1153. doi: 10.1002/jmri.25459

Figure 1. Serial in vivo MRI of carotid arteries with RGD-HFn-Fe3O4 or HFn-Fe3O4.

Figure 1

Figure 1

(A) The ligated left carotid arteries (red arrows) were smaller than the non-ligated right carotid arteries (yellow arrows) prior to RGD-HFn-Fe3O4 or HFn-Fe3O4 injection (Pre). After the injection, T2* signal loss of the ligated left carotid artery was seen at 24 and 48 hours in both RGD+ and RGD− mice, but was greater in RGD+ mice. Luminal area reduction was not seen in the control (non-ligated) right carotid artery in either group. (B) By quantitative analysis, the ligated left carotid artery showed significant % reduction in lumen area (% lumen loss) at 24 and 48 hours in both RGD+ and RGD− groups, but the % lumen loss of RGD+ group was significantly greater. The control right carotid artery showed minimal % lumen loss in both groups.

* p<0.001 vs. Pre, p<0.001 vs. right carotid, † p=0.02 vs. RGD− group, †† p=0.01 vs. RGD− group, ‡ p<0.05 vs. Pre, p<0.05 vs. right carotid