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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Biophys Rev. 2014 Jul 19;6(3):261–272. doi: 10.1007/s12551-014-0142-6

Fig. 2.

Fig. 2

a Schematic diagram of TEP domain structure. The furin-sensitive cleavage site before the ANA domain in complement is called the ‘protease-sensitive’ region for iTEPs and the ‘bait region’ for A2M. The MG8 domain in complement and iTEPs is called the RBD for A2M. b Crystal structures of TEPs in pre-activation states: C3, C4, C5, and AgTEP1. c Crystal structures of TEPs in post-activation states: C3b, C5b, and A2M-MeNH2. Domains in (b, c) are colored according to their position in (a)