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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Biophys Rev. 2014 Jul 19;6(3):261–272. doi: 10.1007/s12551-014-0142-6

Fig. 4.

Fig. 4

a Exploded view of the AgTEP1 TED-MG8 interface, highlighting distinct allotypes for the catalytic loop and the α3-α4 loop. b The crystal structure of the heterodimeric complex of LRIM1/APL1C, the helix-loop-helix (HLH) motif indicated by the boxed region. c Scale comparison of C3a, C5a and LRIM/APL1C HLH motif. d Current model of AgTEP1 regulation by LRIM1/APL1C. Short and long rounded rectangles represent the N- and C-terminal chains of TEP1, joined by a curved line representing the protease-sensitive, which is constitutively cleaved in the insect hemolymph. A yellow star indicates an intact thioester bond