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. Author manuscript; available in PMC: 2017 Aug 28.
Published in final edited form as: Cochrane Database Syst Rev. 2016 Aug 28;(8):CD008815. doi: 10.1002/14651858.CD008815.pub4
OC desogestrel 75 µg compared with no hormonal contraceptive for effect on weight
Patient or population: perimenopausal women with need for contraception
Settings: clinic
Intervention: OC containing desogestrel 75 µg
Comparison: no hormonal contraceptive
Outcomes by 1 year Relative effect
(95% CI) 		Participants
(study) 		Quality of the evidence
(GRADE)
Change in fat mass (%);
change in fat free mass (%)		 MD 3.30 (2.08 to 4.52);
MD −3.30 (−4.52 to −2.08)		 68
(Napolitano 2015)		 Low
CI: Confidence interval; MD = mean difference
GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and
may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is
likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

OC: oral contraceptive