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PET and behavioral data in the macaques. Typical 11C-CFT PET coronal images of dopamine transporter binding are shown before and after MPTP lesioning (a). After MPTP, binding potential was decreased on average by 52 ± 11% (b). Average global locomotor activity (c) measured by automated activity monitors was decreased after the lesion, and the time to perform a computerized reaching task (d) was significantly increased.
