Table 3.

Severity of chemotherapy-induced peripheral neuropathy symptoms (CIPN-sx) at baseline, 1-month, and 1-year time points

	Baseline (pre-treatment)				One-month time pointa				One-year time pointb
FACT/GOG-Ntx item	Ctx+	Ctx−	α c	Significance	Ctx+	Ctx−	α c	Significance	Ctx+	Ctx−	α c	Significance
Sensory symptoms
Numbness/tingling in hands	0.32 (0.9)	0.27 (0.7)	0.050	0.986	1.4 (1.5)	0.27 (0.8)	0.003	0.002	1.3 (1.4)	0.27 (0.9)	0.008	0.001
Numbness/tingling in feet	0.14 (0.5)	0.41 (1.0)	0.034	0.355	1.5 (1.6)	0.09 (0.3)	0.002	0.001	1.1 (1.4)	0.41 (1.1)	0.016	0.013
Discomfort in hands	0.27 (0.9)	0.32 (0.7)	0.037	0.473	1.2 (1.5)	0.32 (0.7)	0.012	0.012	0.95 (1.2)	0.55 (1.0)	0.043	0.142
Discomfort in feet	0.23 (0.5)	0.50 (1.0)	0.035	0.405	1.3 (1.5)	0.59 (1.1)	0.018	0.055	1.9 (1.3)	1.1 (1.5)	0.042	0.608
Motor symptoms
Joint pain or muscle cramps	0.86 (1.1)	0.91 (1.2)	0.049	0.949	1.4 (1.4)	1.3 (1.2)	0.045	0.844	1.6 (1.3)	1.6 (1.4)	0.044	0.772
Feel weak all over	0.41 (0.9)	0.27 (0.6)	0.045	0.860	1.6 (1.5)	0.45 (0.7)	0.005	0.003	1.0 (1.1)	0.4 (0.9)	0.016	0.021
Trouble walking	0.27 (0.6)	0.36 (0.5)	0.030	0.277	0.68 (1.0)	0.68 (0.7)	0.040	0.550	0.67 (1.0)	0.9 (0.9)	0.031	0.296
Auditory symptoms
Trouble hearing	0.41 (1.1)	0.55 (0.7)	0.024	0.152	0.59 (1.2)	0.59 (0.7)	0.032	0.338	0.55 (1.2)	1.0 (1.0)	0.019	0.071
Ringing/buzzing in ears	0.23 (0.8)	0.00 (0.0)	0.027	0.153	0.59 (1.0)	0.05 (0.2)	0.010	0.009	0.55 (0.9)	0.05 (0.2)	0.014	0.018
Functional symptoms
Trouble buttoning buttons	0.23 (0.8)	0.00 (0.0)	0.026	0.153	0.55 (1.1)	0.00 (0.0)	0.006	0.004	0.55 (0.9)	0.00 (0.0)	0.004	0.002
Trouble feeling the shape of small objects in hand	0.32 (1.0)	0.32 (0.7)	0.034	0.352	0.64 (0.7)	0.41 (0.7)	0.022	0.141	0.45 (0.7)	0.55 (1.1)	0.048	0.895
Total scores
Sensory domain	0.95 (2.4)	1.5 (2.9)	0.042	0.656	5.4 (5.6)	1.3 (1.8)	0.005	0.006	4.8 (3.9)	2.3 (3.1)	0.015	0.021
Motor domain	1.6 (2.7)	1.5 (1.8)	0.041	0.575	3.6 (3.0)	2.1 (1.9)	0.019	0.110	3.1 (2.8)	2.5 (2.8)	0.036	0.419
Hearing domain	0.68 (1.5)	0.91 (1.0)	0.021	0.127	1.3 (1.9)	1.3 (1.3)	0.036	0.524	1.2 (1.8)	1.8 (1.8)	0.028	0.157
Functional domain	0.45 (1.7)	0.00 (0.0)	0.025	0.153	1.1 (2.0)	0.05 (0.2)	0.009	0.007	1.1 (1.7)	0.05 (0.2)	0.006	0.004
Total FACT-GOG/Ntx score	3.7 (6.8)	3.9 (4.1)	0.047	0.894	11.4 (10.3)	4.7 (3.4)	0.017	0.034	9.9 (8.3)	6.7 (5.5)	0.022	0.148

Note Values in italics are statistically-significant

The severity of CIPN-sx were expressed as mean (SD) FACT/GOG-Ntx scores. Differences between in the distributions of FACT/GOG-Ntx scores between Ctx+ and Ctx− at each time point were tested using Mann-Whitney U tests, (α=0.05). Differences between total FACT/GOG-Ntx scores were compared using independent samples t-tests

Ctx+ women with breast cancer treated with surgery and/or radiation and chemotherapy, Ctx− women with breast cancer treated with surgery and/or radiation but no chemotherapy

^aOne month following chemotherapy completion or yoked interval for Ctx−

^bOne year following one-month time point.

^cValues represent Benjamin-Hochberg corrected alpha (α) levels used to reduce the risk of a type I error during multiple comparisons