Table VI.

Summary of previous DTI studies that have reported white matter alterations in FASD in regions similar to those found in this study

	FAS/PFAS		HE		Previous studies
Region	FA	MD	FA	MD	References	Subjects’ age (years)	Methods	Results
L-ILF	↓	↑	↓	↑	Lebel et al., 2008	5–12	Semiautomated tractography	FA↓
R-ILF	↓	↑			Lebel et al., 2008	5–12	Semiautomated tractography	FA↓,MD↑
					Sowell et al., 2008a	7–15	Voxelwise	FA↓
SCC	↓	↑	↓	↑	Sowell et al., 2008b	7–15	Voxelwise	FA↓
					Lebel et al., 2008	5–12	Semiautomated tractography	FA↓
					Ma et al., 2005	18–25	Manually defined tractography	FA↓,MD↑
					Wozniak et al., 2009	10–17	Manually defined tractography	FA↓
ICC	↓	↑		↑	Wozniak et al., 2006	10–19	Manually defined tractography	MD↑
					Wozniak et al., 2009	10–17	Manually defined tractography	FA↓
					Li et al., 2009	8–18	TBSS	FA↓
					Fryer et al., 2009	19–27	TBSS	FA↓
R-SLF		↑			Lebel et al., 2008	5–12	Semiautomated tractography	FA↓
					Fryer et al., 2009	19–27	TBSS	FA↓
L-CST		↑			Lebel et al., 2010	5–13	Voxelwise	FA↓
R-CST		↑		↑	Lebel et al., 2008	5–12	Semiautomated tractography	MD↑

L = left, R = right; FA = fractional anisotropy; MD = mean diffusivity.

FAS/PFAS = combined fetal alcohol syndrome (FAS) and partial FAS (PFAS) group; HE = nonsyndromal heavily exposed group.

ILF = inferior longitudinal fasciculus; SCC = splenium of corpus callosum; ICC = isthmus of corpus callosum; SLF = superior longitudinal fasciculus; CST = corticospinal tract.

^aThe coordinate where the maximum MD difference (42, −29, −12) in the R-ILF occurred in the FAS/PFAS vs Ctl comparison overlapped with the maximum FA difference (45, −22, −15) seen in the Sowell et al. [2008] study. ^bCoordinates where the peak FA (−8, −39, 18) and MD (−10, −36, 18) differences occurred in the SCC in the FAS/PFAS vs Ctl comparison were close to the SCC regions (MNI coordinates: (−14, −50, 15) and (−4, −43, 18)) seen in the Sowell et al. [2008] study.