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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Cell Mol Life Sci. 2016 Sep 19;74(3):495–508. doi: 10.1007/s00018-016-2359-y

Figure 2. Schematic summary of molecular configuration of Kv7 channel and its modulation modified from ref 29.

Figure 2

A) Activation of Gq/11 coupled receptor induces depletion of PIP2 as well as activation of PKC, which phosphorylates Kv7 channel leading to dissociation of CaM and unstabilized PIP2 interaction. B) Increase in cytosolic calcium induces change in CaM conformation, and configuration between CaM and Kv7 channel, which leads to unstalized PIP2 interaction.