Table 2.
Replication populations
| Variable | MGH | ERICH | University of Brescia |
UMC Utrecht | University of Edinburgh |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case | Ctrl | Case | Ctrl | Case | Ctrl | Case | Ctrl | Case | Ctrl | |
| n | 240 | 458 | 920 | 826 | 198 | 185 | 157 | 160 | 110 | 216 |
| Age, n (SD) | 76 (10) |
69 (11) |
69 (14) |
68 (13) |
69 (13) |
63 (14) |
62 (13) |
56 (11) |
75 (9) | 76 (10) |
| Female, n (%) |
96 (40) |
206 (45) |
397 (43) |
371 (45) |
81 (41) |
85 (46) |
66 (42) |
67 (42) |
59 (54) |
118 (54) |
| Lobar , n (%) | 120 (48) |
- | 380 (41) |
- | 82 (41) |
- | 60 (38) |
- | 61 (55) |
- |
| Genotyping platform |
iPLEX | iPLEX | Taq- man |
Taq- man |
iPLEX | iPLEX | iPLEX | iPLEX | iPLEX | iPLEX |
| Replication Totals |
3470 individuals (1625 cases, 1845 controls), 42% lobar ICH | |||||||||
| Discovery + Replication Totals |
5625 individuals (2595 cases, 3030 controls), 45% lobar ICH | |||||||||
Abbreviations: Ctrl = Control; ERICH = Ethnic/Racial Variations of Intracerebral Hemorrhage; iPLEX = Sequenom MassARRAY iPLEX Platform; MGH = Massachusetts General Hospital; TaqMan = Applied Biosystems Taqman Genotyping Assay