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. Author manuscript; available in PMC: 2016 Dec 2.
Published in final edited form as: Ann Neurol. 2016 Oct 19;80(5):730–740. doi: 10.1002/ana.24780

Table 4.

Discovery SNP rs173539 and local proxies in association with ICH risk

SNP CHR Tested
allele		 MAF Effect
direction		 OR SE Discovery
p		 I2
rs173539 16 T 0.31 +++ 1.25 0.06 6.00×10−4 0
 -- rs247617 (r2=0.99) 16 A 0.31 +++ 1.24 0.06 8.74×10−4 0
 -- rs17231506 (r2=0.99) 16 T 0.31 +++ 1.23 0.06 9.13×10−4 0
 -- rs711752 (r2=0.62) 16 A 0.42 ++− 1.15 0.06 2.08×10−2 14
 -- rs708272 (r2=0.61) 16 A 0.42 ++− 1.15 0.06 2.23×10−2 18

Association results for rs173539 in association with ICH risk, as well as four additional SNPs in linkage disequilibrium (LD) with rs173539 chosen for replication. CHR = chromosome, MAF = minor allele frequency, OR = odds ratio, SE = standard error, r2 = degree of LD with rs173539. SNP = single nucleotide polymorphism, + = variant increases ICH risk, − = variant decreases ICH risk.