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. Author manuscript; available in PMC: 2009 Jan 8.
Published in final edited form as: Acta Crystallogr D Biol Crystallogr. 2008 Aug 13;64(Pt 9):977–984. doi: 10.1107/S0907444908022348

Fig. 5.

Fig. 5

Difference electron density (2Fo-Fc, 1σ) for the holo complex with cofactor, NADPH in mouse DHFR. The density in the active site was fit to glycerol from the cryo protection in the buffer.