Table 5.
Timepoints | Estimated change ± SE and % change | ||||||||
---|---|---|---|---|---|---|---|---|---|
0 | 6 mo | 12 mo | 0–6 mo | % | 6–12 mo | % | 0–12 mo | % | |
Trabecular vBMD |
201.2 | 207.0 | 199.0 | 6.2±5.4 | 3.1 | −8.5±6.2 | −4.1 | −2.2±8.1 | −1.1 |
Trabecular CSA |
544.0 | 680.0 | 627.0 | 136.1±66.7 | 25.0 | −52.8±75.8 | −7.8 | 83.3±99.9 | 15.3 |
Cortical vBMD |
1111.6 | 1129.0 | 1134.0 | 17.0±25.1 | 1.5 | 5.7±28.3 | 0.5 | 22.7±35.4 | 2.0 |
Cortical CSA |
178.8 | 175.0 | 171.0 | −3.6±7.2 | −2.0 | −4.0±8.1 | −2.3 | −7.6±10.2 | −4.2 |
Cortical BMC |
202.2 | 198.5 | 195.8 | −3.7±7.4 | −1.8 | −2.7±8.4 | −1.4 | −6.4±10.5 | −3.2 |
Cortical thickness |
3.99 | 4.01 | 3.97 | 0.03±0.1 | 0.8 | −0.04±0.11 | −1.0 | −0.02±0.14 | −0.5 |
BSI | 60.8 | 60.0 | 58.0 | −1.0±1.5 | −1.6 | −1.6±1.7 | −2.7 | −2.6±2.2 | −4.3 |
Zp | 1042.7 | 998.0 | 928.0 | −44.8±46.9 | −4.3 | −70.1±53.0 | −7.0 | −115.0±66.3 | −11.0 |
SSI | 928.1 | 886.0 | 834.0 | −41.6±37.0 | −4.5 | −52.2±41.9 | −5.9 | −93.8±52.3 | −10.1 |
Data are shown as adjusted means for the tibia length, estimated change ± SE, and percent change. BMC, bone mineral content (mg/mm); BSI, bone strength index is expressed in mg2/mm4; cortical thickness is expressed in mm; CSA, cross-sectional area (mm2); vBMD, volumetric bone mineral density (mg/cm3); Zp, polar section modulus and SSI, strength strain index are expressed in mm3.