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A. Chemical structures of DSM265 and DSM421. B. X-ray structure of PfDHODH bound to DSM421. The inhibitor binding-site showing limited residues within the 4Å shell of DSM421 is displayed. DSM421 is displayed with a dot surface representative of the van der Waals surface. Colors are as follows: DSM421, FMN and orotate carbons tan, protein carbons purple, oxygens red, nitrogens blue, sulfurs yellow, phosphates orange and fluorines turquoise.
