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. Author manuscript; available in PMC: 2016 Dec 10.
Published in final edited form as: ACS Infect Dis. 2016 Oct 4;2(12):945–957. doi: 10.1021/acsinfecdis.6b00144

Figure 3.

Figure 3

P. falciparum and mammalian cell growth inhibition by DSM421. A. Dose response of DSM421 versus P. falciparum 3D7 cells EC50 = 0.014 (0.013 – 0.015) μM and on D10 cells transfected with yeast DHODH (EC50 > 10 μM). B. Dose response of DSM421 (EC50 > 50 μM) and 5-fluoroorotate (EC50 = 0.77 (0.71 – 0.83) μM versus Human HepG2 cells. Data in A and B were fitted in GraphPad Prism to log(inhibitor) vs. response – Variable slope (four parameter) fit equation to determine the EC50 (data in parenthesis show the 95% confidence interval for the fit). Triplicate data were collected per concentration point and error represents the standard deviation of the mean.