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Oral (PO) and intravenous (IV) pharmacokinetic profiles after a single dose of DSM421 in A) mice, B) rats and C) dogs. Dose levels are indicated on the graph. Data represent the mean ± range of n=2 samples per time point for mice and n= 2 rats, or mean ± SD for n=3 dogs. Dosing conditions are described in Table S14.
