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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Chem Sci. 2016 May 18;7(8):5453–5461. doi: 10.1039/c6sc00826g

Figure 4.

Figure 4

Design of the DNA-binding peptide P8. (a) The V-shaped cyt cb562 dimer dictated by NiII coordination to the His/Quin HCMs (green) (PDB ID: 3L1M). Adapted from reference 39. (b) Backbone superposition of the Helix3 domains of HCM-modified cyt cb562 (black) onto the basic domain of Jun bZip homodimer (magenta) complexed with cAMP responsive element (CRE) (brown) (PDB ID = 1JNM). (c) Overall architecture and structural components of P8, and its proposed Ni-induced dimerization geometry based on the structural model in (b).