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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Chem Sci. 2016 May 18;7(8):5453–5461. doi: 10.1039/c6sc00826g

Table 1.

Dissociation constants and extents of helicity for peptide-metal complexes. Discussion of binding models, formulas for calculating helicity, and additional figures can be found in the Supporting Information. The helicity of the metal-free peptide was measured in 60% TFE to obtain the maximum expected helical signal.

Metal Kd, His-Phen HCM (M) Kd free Phen1 (M) Calculated Helicity (at 25 °C) Percent of maximum helicity
Metal-free N/A N/A 17% 30%
CoII 3(2) × 10-8 8.0 × 10-8 38% 69%
NiII 3(2) × 10-11 3.9 × 10-8 43% 77%
CuII 6(5) × 10-13 2.5 × 10-9 18% 32%
ZnII 1.7(7) × 10-8 3.7 × 10-7 34% 62%