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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Chem Sci. 2016 May 18;7(8):5453–5461. doi: 10.1039/c6sc00826g

Table 2.

Kinetic parameters for the tryptic digestion of P3 under various conditions.

Metal Rate (s-1) Half-life (min) Enhancement over metal-free HCM
4 °C
Metal-free: P3bare 2.0(1) × 10-3 6 0.8
NiII: P3bare 1.7(3) × 10-3 7 0.9
Metal-free 1.6(2) × 10-3 7 1
NiII 1.7(2) × 10-5 700 96.7
CuII 1.9(2) × 10-4 60 8.4
ZnII 4.1(6) × 10-5 280 38.8
25 °C
Metal-free 5.0(6) × 10-3 2 1
NiII 1.1(1) × 10-4 106 53
CuII 2.3(2) × 10-3 5 2.5