Computer simulation of the streamlines of the bulk blood flow through the network ladder predicts a flow distortions at the intersection of the first bypass (bp 1; resulting in a zone of recirculation), at the stoppered channel (black bar), and at channel 2 (A). Simulation of blood cell transport during thrombus formation: < 50% of bypass obstruction, left, and > 50% bypass obstruction, right (B); shear rate profile (C) and thrombin convection profile mol/m3 (D) within these regions.