TABLE III.
Effect of micro-motion on estimates of cortical gray matter volume, surface area, cortical thickness and surface curvature (CIVET pipeline and FreeSurfer pipeline) for adult sample only
| CIVET processing pipeline | FreeSurfer processing pipeline | |||||
|---|---|---|---|---|---|---|
| Anatomical metric |
Change per 0.1 mm framewise motion (95% CI) |
t statistic |
P (FDR-corrected) |
Change per 0.1 mm framewise motion (95% CI) |
t statistic |
P (FDR-corrected) |
| Total brain volume | ||||||
| Gray matter | −47.1 cm3 (−92.7, −1.5) | −2.02 | 0.049 | −42.8 cm3 (−76.6, −9.0) | −2.48 | 0.016 |
| White matter | −22.3 cm3 (−54.7, 10.1) | −1.35 | 0.184 | −33.5 cm3 (−67.3, 0.3) | −1.95 | 0.057 |
| CSF | −6.8 cm3 (−23.2, 9.6) | −0.82 | 0.429 | −2.08 cm3 (−6.8, 2.7) | −0.86 | 0.39 |
| Lobar volume | ||||||
| Frontal | −17.0 cm3 (−31.0, −3.1) | −2.39 | 0.027 | −13.3 cm3 (−24.4, −2.3) | −2.38 | 0.042 |
| Parietal | −3.0 cm3 (−10.7, 4.8) | −0.75 | 0.458 | −3.9 cm3 (−12.7, 4.9) | −0.86 | 0.10 |
| Temporal | −14.5 cm3 (−26.0, −3099) | −2.49 | 0.027 | −8.4 cm3 (−14.9, −1.9) | −2.53 | 0.042 |
| Occipital | −7.0 cm3 (−12.4, −1.6) | −2.55 | 0.027 | −3.6 cm3 (−7.2, 0.1) | −1.92 | 0.08 |
| Lobar surface area | ||||||
| Frontal | −37.2 cm2 (−68.1, −6.4) | −2.36 | 0.056 | −42.4 cm2 (−79.3, −5.5) | −2.26 | 0.11 |
| Parietal | −5.6 cm2 (−28.1, 16.8) | −0.49 | 0.626 | −15.8 cm2 (−45.3, 13.8) | −1.05 | 0.30 |
| Temporal | −21.1 cm2 (−39.3, −2.8) | −2.26 | 0.056 | −16.9 cm2 (−35.5, −1.7) | −1.78 | 0.16 |
| Occipital | −9.7 cm2 (−22.5, 3.1) | −1.49 | 0.190 | −9.4 cm2 (−23.4, 4.6) | −1.32 | 0.26 |
| Lobar cortical thickness | ||||||
| Frontal | −0.077 mm (−.187, 0.033) | −1.37 | 0.237 | −0.011 mm (−0.081, 0.059) | −0.30 | 0.93 |
| Parietal | −0.0568 mm (−0.154, 0.041) | −1.14 | 0.258 | 0.003 mm (−0.0071, 0.079) | 0.09 | 0.93 |
| Temporal | −0.111 mm (−0.215, −0.007) | −2.09 | 0.082 | −0.084 mm (−0.154, 0.013) | −2.33 | 0.09 |
| Occipital | −0.113 mm (−0.24, −0.0257) | −2.43 | 0.074 | −0.027 mm (−0.081, 0.027) | −0.99 | 0.66 |
| Lobar mean curvature | ||||||
| Frontal | 0.0041 mm−1 (0.0010, 0.0072) | 2.61 | 0.02 | |||
| Parietal | 0.0037 mm−1 (0.0007, 0.0066) | 2.42 | 0.03 | |||
| Temporal | 0.0049 mm−1 (0.0017, 0.0080) | 3.06 | 0.01 | |||
| Occipital | 0.0040 mm−1 (−0.0007, 0.0089) | 1.64 | 0.11 | |||
| Lobar Gaussian curvature | ||||||
| Frontal | 0.097 mm−2 (−0.067, 0.26) | 1.16 | 0.33 | |||
| Parietal | 0.014 mm−2 (−0.005, 0.033) | 1.47 | 0.29 | |||
| Temporal | 0.019 mm−2 (0.002, 0.036) | 2.16 | 0.14 | |||
| Occipital | −0.011 mm−2 (−0.043, 0.022) | −0.64 | 0.52 | |||
Statistical association with micro-motion for CIVET and FreeSurfer output, for subjects 18 years or over only. Linear models were fit in R with age and gender as covariates. N = 58 subjects (27 females); mean age = 23.4 (sd = 3.8, range = 18–34); average framewise motion = 0.08 mm (sd = 0.04, range = 0.02–0.27); one scan per family