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. Author manuscript; available in PMC: 2017 Apr 6.
Published in final edited form as: Anat Rec (Hoboken). 2017 Jan 11;300(3):560–576. doi: 10.1002/ar.23511

Figure 4.

Figure 4

Body Features of 150 day-old Mice. A. Body Weight: Although JTMT mice weighed slightly less than other genotypes, of the four genotypes utilized in the current study, no group varied more than 15% from any other. B: Combined weight of left and right kidneys. Total renal weight was significantly greater (~86%) in OVE animals than in non-diabetic controls, but diabetic nephromegaly was mitigated significantly by breeding with JTMT mice, reducing the average weight in OVE-JTMT mice by ~29%. C. Blood Sugar. Serum glucose frequently reached 600mg/dl in OVE mice, and these levels were not mitigated by overexpression of MT. D: Likewise, HbA1c rose to more than 10% in severely diabetic OVE mice, and was maintained at highest levels with or without EC targeted MT.