Figure 1. Spontaneous relapse after suppression of Ras oncogene expression in mice with NRAS(V12)-driven AML.
White blood cell (WBC) counts of leukemic SCID Beige mice with NRAS(V12)-dependent (NRD) AML rapidly decline after doxycycline (Dox)-mediated suppression of NRAS(V12) expression. Two of 5 mice spontaneously relapsed with NRAS(V12)-independent AML (NRI1 and NRI1 AMLs) despite continued Dox treatment.