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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Hepatology. 2017 Jan 10;65(4):1278–1292. doi: 10.1002/hep.28947

Fig. 4. The SRL portion of TRTRVSRLY has an effect on viral binding and replication.

Fig. 4

(A, B) Mouse cholangiocytes pre-treated with TRTRSVRLY or synthetic peptides with altered aa at positions 440 (T→M) or 446 (R→G). Altering aa 440 had a similar effect as TRTRVSRLY while a peptide containing an altered aa 446 could not inhibit RRV binding or replication. (C, D) Cholangiocytes pre-treated with 1 mM of synthetic peptides with single aa changes from VSRLY. Peptides conserving the “SRL” portion maintained the peptide’s ability to block RRV binding and replication. Peptides with an altered single aa between 445–447 lost the ability to block RRV binding and replication. * = p<0.05 compared to serum free media.