Estimation of estimating both shape and appearance changes from 2-week-old, 3-month-old, 6-month-old, and 9-month-old to the 12-month-old template image (a). From top to bottom row, we respectively show the original subject images, the deformed subject images after applying the learned patchwise appearance-displacement model, and the deformed subject images after applying both the learned patchwise appearance-displacement and appearance-appearance models at 2-week-old (b), 3-month-old (c), 6-month-old (d), and 9-month-old (e). It can be observed that both anatomical and appearance discrepancies have been largely decreased after applying these two learned models.