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. Author manuscript; available in PMC: 2017 Jan 11.
Published in final edited form as: Tomography. 2016 Dec;2(4):295–307. doi: 10.18383/j.tom.2016.00217

Figure 7.

Figure 7

Influence of S0 estimates on dynamic contrast-enhanced (DCE)-MRI tissue concentration–time curves generated with the proposed method. T1-weighted (first-echo) signal time course for a representative voxel in tumor (A). Calculated tissue concentration–time curve for tumor voxel in (A) generated using S0 estimated without full recovery of longitudinal magnetization (B). With increasing signal enhancement (ie, as the signal approaches S0), the noise in the concentration–time curve is amplified (note the scale on the ordinate). Calculated tissue concentration–time curve for tumor voxel in (A) generated using S0 estimated with full recovery of longitudinal magnetization (C). Allowing full recovery of longitudinal magnetization results in a concentration–time curve shape that closely resembles the signal in (A), prevents amplification of noise during signal enhancement, and reduces error.