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. Author manuscript; available in PMC: 2018 Mar 27.
Published in final edited form as: Epilepsia Open. 2017 Jan 18;2(2):156–161. doi: 10.1002/epi4.12038

FIGURE 1.

FIGURE 1

Flow diagram. A subset of patients from NeuroVista patients were used based on inclusion criteria. To generate one virtual patient, first a randomly chosen patient was selected. Then, 20 windows of duration 1 week were selected, with random start times. The process was repeated 200 times for each clinical trial, which comprised 100 placebo patients and 100 drug patients. The trial was analyzed with the 50% responder rate (RR50) and the median percent change (MPC) method. Some trials were successful (denoted with an exclamation mark) at distinguishing drug from placebo. For each of 5 drug strengths, 1000 trials were simulated.