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. Author manuscript; available in PMC: 2017 Jan 16.
Published in final edited form as: J Neurosci. 2012 Nov 21;32(47):16992–17002. doi: 10.1523/JNEUROSCI.3057-12.2012

Figure 7.

Figure 7

Female GnRH-Itgb1−/− mice show abnormal estrous cyclicity. Vaginal cytology was assessed for 20 d in GnRH-Itgb1+/+ (n = 12) and GnRH-Itgb1−/− mice (n = 12). a, Time in each estrous cycle phase as a percentage of the cycle. GnRH-Itgb1−/− females remained in a predominantly diestrus state with the sporadic occurrence of complete ovarian cycles, whereas control littermates showed a regular estrous cyclicity. Data are represented as means ± SEM. n, number of animals; *p < 0.0001, unpaired Student’s t test. M/D, metestrus/ diestrus; E, estrus; P, proestrus. b, c, Representative estrous cyclicity of control (b) and GnRH-Itgb1−/− mice (c). Control females typically show a regular 4 d ovarian cycle (b), whereas GnRH-Itgb1−/− mice are characterized by with highly irregular cycles (c).